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Psoriasis:: High yield MCQ for MSRA:: Part 1

Updated: Aug 18

 A 25-year-old man presents with an abrupt eruption of multiple 3–8 mm pink tear-drop papules over his trunk and upper arms, 5 days after a sore throat. He is otherwise well.


 Which is the most likely diagnosis?

Choose the correct answer

  • A) Pityriasis rosea

  • B) Guttate psoriasis

  • C) Secondary syphilis

  • D) Lichen planus



  1.  A 34-year-old woman with chronic plaque psoriasis attends review. She has been using morning clobetasol propionate and evening calcipotriol for 8 weeks, but her plaques remain thick and scaly.


     What is the most appropriate next step?

Choose the correct answer

  • A) Switch to calcipotriol twice daily

  • B) Add coal-tar preparation

  • C) Start methotrexate

  • D) Apply very potent steroid twice daily for 12 weeks



  1. A patient with psoriasis develops a new plaque along a surgical scar 10 days after an operation. What is this phenomenon called?

Choose the correct answer

  • A) Woronoff ring

  • B) Auspitz sign

  • C) Munro microabscess

  • D) Koebner phenomenon



  1.  A patient with psoriasis notices pale halos around healing plaques following topical treatment. Which term best describes this?

Choose the correct answer

  • A) Koebner phenomenon

  • B) Woronoff ring

  • C) Candle grease sign

  • D) Auspitz sign



  1.  A 55-year-old man with stable chronic plaque psoriasis is prescribed a topical agent that slows keratinocyte proliferation. After two weeks, he develops irritant dermatitis and complains of brown stains on his clothes. Which drug is most likely responsible?

Choose the correct answer

  • A) Coal tar

  • B) Calcipotriol

  • C) Dithranol

  • D) Salicylic acid



  1.  A 48-year-old man with severe psoriasis presents with worsening pustular rash and fever 3 days after stopping oral prednisolone. What is the most likely diagnosis?

Choose the correct answer

  • A) Drug eruption

  • B) Generalised pustular psoriasis

  • C) Erythroderma

  • D) Staphylococcal scalded skin syndrome



  1.  Which of the following drugs is most strongly associated with triggering psoriasis?

Choose the correct answer

  • A) Amoxicillin

  • B) Atenolol

  • C) Ranitidine

  • D) Carbimazole



  1.  A patient with psoriasis is about to start methotrexate. Which baseline investigations are essential?

Choose the correct answer

  • A) FBC, LFTs, RFT, UPT, hepatitis B/C, HIV, TB screen

  • B) FBC, LFTs, renal function only

  • C) ESR and CRP

  • D) Chest X-ray only



  1.  Histology of a psoriatic plaque is most likely to show which of the following?

Choose the correct answer

  • A) Subepidermal blister with linear IgG at basement membrane

  • B) Hyperkeratosis with Munro microabscesses

  • C) Intraepidermal blister with acantholysis

  • D) Interface dermatitis with basal vacuolation



  1.  A patient with stable plaque psoriasis on vitamin D analogue therapy develops hypercalcaemia. What is the most appropriate action?

Choose the correct answer

  • A) Continue treatment and increase fluids

  • B) Stop vitamin D analogue

  • C) Start bisphosphonate

  • D) Reduce dietary calcium


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